Aquaporin-5

AQP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442; MGI: 106215; HomoloGene: 20398; GeneCards: AQP5; OMA:AQP5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,965,682 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,492,710 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	362
	11830
	ENSG00000161798
	ENSMUSG00000044217
	P55064
	Q9WTY4
	NM_001651
	NM_009701
	NP_001642
	NP_033831
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.^[5]^[6]

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions.^[6] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.^[6]

AQP-5 features a homotetrameric structure embedded in the cell membrane with the center of each monomer acting as a water pore.^[7] Each monomer structure is a transmembrane protein which have an asparagine–proline–alanine (NPA) hydrophobic residue embedded in the membrane of the cell. The NPA residue plays a role in water and solute permeability across the membrane of the cell..^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161798 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, et al. (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". Journal of Biological Chemistry. 271 (15): 8599–8604. doi:10.1074/jbc.271.15.8599. PMID 8621489.
^ ^a ^b ^c "Entrez Gene: AQP5 aquaporin 5".
^ ^a ^b Direito I, Madeira A, Brito MA, Soveral G (Apr 2016). "Aquaporin-5: from structure to function and dysfunction in cancer". Cellular and Molecular Life Sciences : CMLS. 73 (8): 1623–1640. doi:10.1007/s00018-016-2142-0. PMC 11108570. PMID 26837927.

Verkman AS (Feb 2003). "Role of aquaporin water channels in eye function". Experimental Eye Research. 76 (2): 137–143. doi:10.1016/S0014-4835(02)00303-2. PMID 12565800.
Ma T, Yang B, Umenishi F, Verkman AS (Aug 1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–389. doi:10.1006/geno.1997.4836. PMID 9268644.
Smith JK, Siddiqui AA, Modica LA, Dykes R, Simmons C, Schmidt J, et al. (Aug 1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. 19 (8): 929–935. doi:10.1089/107999099313479. PMID 10476940.
Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC, Gabriel SE (Mar 2001). "Expression and localization of epithelial aquaporins in the adult human lung". American Journal of Respiratory Cell and Molecular Biology. 24 (3): 224–234. doi:10.1165/ajrcmb.24.3.4367. PMID 11245621. S2CID 12825671.
Gresz V, Kwon TH, Hurley PT, Varga G, Zelles T, Nielsen S, et al. (Jul 2001). "Identification and localization of aquaporin water channels in human salivary glands". American Journal of Physiology. Gastrointestinal and Liver Physiology. 281 (1): G247 – G254. doi:10.1152/ajpgi.2001.281.1.G247. PMID 11408278.
Nejsum LN, Kwon TH, Jensen UB, Fumagalli O, Frokiaer J, Krane CM, et al. (Jan 2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 511–516. Bibcode:2002PNAS...99..511N. doi:10.1073/pnas.012588099. PMC 117591. PMID 11773623.
Burghardt B, Elkaer ML, Kwon TH, Racz GZ, Varga G, Steward MC, et al. (Jul 2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–1016. doi:10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chen Z, Wang X, Gao L, Bai L, Zhu R, Bai C (Apr 2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochemical and Biophysical Research Communications. 342 (3): 775–781. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.
Sidhaye VK, Guler AD, Schweitzer KS, D'Alessio F, Caterina MJ, King LS (Mar 2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proceedings of the National Academy of Sciences of the United States of America. 103 (12): 4747–4752. Bibcode:2006PNAS..103.4747S. doi:10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
Pedersen PS, Braunstein TH, Jorgensen A, Larsen PL, Holstein-Rathlou NH, Frederiksen O (Mar 2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflugers Archiv : European Journal of Physiology. 453 (6): 777–785. doi:10.1007/s00424-006-0157-3. PMID 17043812. S2CID 6205954.
Skowron-zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F (Jul 2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Experimental Cell Research. 313 (12): 2695–2702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.

External links

AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161798 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044217 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lee_1996-5] Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, et al. (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". Journal of Biological Chemistry. 271 (15): 8599–8604. doi:10.1074/jbc.271.15.8599. PMID 8621489.

[entrez-6] "Entrez Gene: AQP5 aquaporin 5".

[Direito_2016-7] Direito I, Madeira A, Brito MA, Soveral G (Apr 2016). "Aquaporin-5: from structure to function and dysfunction in cancer". Cellular and Molecular Life Sciences : CMLS. 73 (8): 1623–1640. doi:10.1007/s00018-016-2142-0. PMC 11108570. PMID 26837927.

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Conheça Walt Disney World

Aquaporin-5

References

Further reading

External links