Muko may refer to:

• Mukō, Kyoto, Japan
• The Mukogawa River
• Muko Jima, Bonin Islands, Japan
• Muko Station, a railway station on the Hakubi Line in Kōfu, Tottori Prefecture, Japan
• Muko, Rwanda in Gikongoro District, Rwanda
• Muko, Uganda in Kabale District, Uganda