SACS may refer to:

• SACS, a finite element analysis software by Bentley Systems
• SACS (gene), a human gene that encodes the protein Sacsin
• The South Atlantic Cable System, a transoceanic submarine communications cable
• Saint Alphonsus Catholic School, a Catholic School found at Lapu-Lapu City, Cebu, Philippines
• St Andrew's Cathedral School, an Anglican school in Sydney, Australia
• The South African College Schools, a school in Cape Town, South Africa
• The Southern Association of Colleges and Schools, an educational accreditation body in the southern United States
• Success Academy Charter Schools
• Southwest Allen County Schools, a school district in Indiana
• Structural Analysis of Cultural Systems, an NGO
• Suzuki Advanced Cooling System, used in some Suzuki motorcycle engines

• Sacs, an alternate name for the Sauk, a native American people